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Flow Modulator INSIGHT®


SepSolve Analytical

Outstanding performance for routine GC×GC


The INSIGHT flow modulator from SepSolve overcomes the cost and logistical issues of the liquid cryogen needed for thermally-modulated systems. In addition, it provides separation of volatiles from C1 to C40+, no modulation breakthrough for improved characterisation of both large and small peaks, built-in splitting for use with multiple detectors, and compatibility with heart-cutting 2D GC.

To work in conjunction with the INSIGHT flow modulator, SepSolve also offers the comprehensive ChromSpace®  software for GC×GC.

Reverse fill/flush dynamics technology was first developed by Dow Chemical in 2011: A reversed-flow differential flow modulator for comprehensive two-dimensional gas chromatography, Journal of Chromatography A, 2011, 1226: 116-123. DOI: 10.1016/j.chroma.2011.11.036.

Notes d'application
Reliable speciation of fatty acid methyl esters (FAMEs) by flow-modulated GC×GC–TOF MS/FID with Tandem Ionisation

This study demonstrates the use of flow-modulated GC×GC to analyse a FAME standard and FAMEs from a butter extract, with simultaneous detection by TOF MS and FID for improved speciation.

Taille du fichier: 703 Ko
Flavour profiling of milk using high‑capacity sorptive extraction and TD–GC×GC–TOF MS/FID

This study demonstrates the high performance of PDMS sorptive extraction probes, coupled with thermal desorption pre‑concentration and INSIGHT™ flow-modulated GC×GC–TOF MS/FID analysis, for the separation and identification of flavour compounds in milk.

Taille du fichier: 982 Ko
Comprehensive analysis of coffee bean extracts by GC×GC–TOF MS

This study shows that GC×GC with time-of-flight mass spectrometry provides a high-performance solution for screening complex coffee-bean extracts for key aroma compounds.

Taille du fichier: 1 014 Ko
Comparison of aroma compounds in whisky by SPME–GC×GC–TOF MS/FID

This study demonstrates the high performance of a flow-modulated GC×GC–TOF MS system, coupled with sample preparation by solid-phase micro-extraction (SPME), for the separation and identification of trace volatiles in three brands of whisky. 

Taille du fichier: 816 Ko
Comprehensive analysis of tobacco smoke using TD–GC×GC–TOF MS with Tandem Ionisation

In this study, we use thermal desorption (TD) for collection and analysis of whole cigarette emissions, and couple it with flow-modulated GC×GC–TOF MS, to enable smoke constituents to be routinely and confidently sampled, separated and identified.

Taille du fichier: 582 Ko
Tackling the extended list of fragrance allergens by flow-modulated GC×GC–TOF MS/FID

This preliminary study investigates the use of flow-modulated GC×GC to analyse an 84-component allergen calibration standard, with simultaneous detection by TOF MS for confident identification and FID for robust quantitation.

Taille du fichier: 2 Mo
Enhanced separation of hop oils by flow-modulated GC×GC–TOF MS

This study demonstrates the high performance of a flow-modulated GC×GC–MS system for the evaluation of complex hop oils, which allows effective modulation of even the most volatile components without the need for expensive liquid cryogen.

Taille du fichier: 696 Ko
Detailed characterisation of essential oils by flow-modulated GC×GC and Tandem Ionisation mass spectrometry

In this study, flow-modulated GC×GC–TOF MS with Tandem Ionisation is used to characterise essential oils in fine detail, allowing the indepth comparison of their compositions that aids rigorous quality control, particularly in the fragrance industry.

Taille du fichier: 642 Ko


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